Shandong Changrui Biotech Co., Ltd. is one of the leading manufacturers and suppliers of inositol nicotinate in China. Please feel free to wholesale bulk high purity inositol nicotinate in stock here from our factory. All our raw materials are with high quality and competitive price. Contact us for pricelist.
Product Introduction
High Purity Inositol Nicotinate is a niacinate derivative formed by esterification of one molecule of inositol and six molecules of niacin, also known as No-Flush Niacin. It hydrolyzes slowly in the human body and releases niacin and inositol gradually. It helps support peripheral vascular condition and cardiovascular health while greatly reducing the skin flush commonly caused by ordinary niacin. Widely used in dietary supplements, pharmaceutical excipients, functional health foods, and cosmetics, it is an ideal ingredient for brands developing flush-free niacin products and cardiovascular support formulations.
Technical Specifications
|
Property |
Specification |
|
Appearance |
Off-white to white crystalline powder |
|
Assay |
98.0% min |
|
Identification |
Complies |
|
Loss on Drying |
0.5% max |
|
Residue on Ignition |
0.1% max |
|
Melting Point |
254-262℃ |
|
Heavy Metals (as Pb) |
10 PPM max |
|
Arsenic (As) |
1.0 PPM max |
|
Lead (Pb) |
0.5 PPM max |
|
Mercury (Hg) |
0.1 PPM max |
|
Cadmium (Cd) |
1.0 PPM max |
|
Bulk Density |
0.70-0.80 g/ml |
|
Total Plate Count |
1000 CFU/g max |
|
Mold & Yeast |
100 CFU/g max |
|
E. coli |
Negative |
Health Benefits & Values
Flush-Free Niacin Source
This esterified B3 releases niacin slowly in the body, delivering cardiovascular benefits without the skin flushing effect and raising end-user acceptance.
Promotes Peripheral Blood Circulation
Relaxes vascular smooth muscle to sustain healthy extremity blood flow, forming a standout selling point for circulation-support supplements.
Supports Balanced Blood Lipids
Regulates hepatic lipid synthesis to maintain healthy LDL, total cholesterol and triglyceride levels for cardiovascular wellness formulations.
Gentle Sustained Nutrient Release
Slow hydrolysis unlocks inositol and niacin steadily, avoiding sudden nutrient spikes and providing prolonged nutritional benefits.
Good Compatibility With Other Nutrients
Pairs safely with B vitamins, minerals and plant extracts, enabling stable multi-component wellness formula development.
Core Value in Formulation Development
Specialised Raw Material for Low-Flush B3 Supplement Designs
Free niacin commonly induces itching and cutaneous flushing, reducing end-user compliance. This ester derivative enables you to develop cardiovascular supplements with far fewer adverse skin reactions.
Sustained Nutrient Release Profile
Its ester linkage supports gradual breakdown inside the human body, which can cut down daily dosing frequency and fits sustained-release tablets and long-acting capsule formulations.
Single Ingredient Delivers Two Functional Moieties
Upon hydrolysis, both inositol and niacin are liberated. This dual-function raw material simplifies your formula recipe and reduces the number of individual ingredients required.
Excellent Thermal Stability
This solid powder has a high melting point of 254–262°C and outstanding heat resistance, maintaining quality during tableting and capsule filling workflows.
Established Safety & Regulatory Acceptance
It has decades of prescription application history in Europe, with reliable safety records for dietary supplement and pharmaceutical active ingredient development.
End-Application Scenarios
Dietary Supplements (Core Track)
Used in tablets and capsules targeting cardiovascular maintenance, flush-free B3 supplementation and lipid management. Recommended daily intake: 500–3000 mg, split into meals.
Pharmaceutical Active Component
Serves as the niacin ester active substance for formulation R&D; widely adopted in European prescription preparations for peripheral circulation management.
Functional Health Foods
Incorporated into multi-vitamin blends and nutritional products designed for cardiovascular and metabolic support.
Cosmetic & Skincare Raw Material
The inositol moiety provides moisturising and conditioning effects, suitable for skincare formulas supporting skin microcirculation and epidermal health.
Biochemical Research Reagents
Deployed in laboratory research covering cell signalling and lipid metabolism studies.
Application Advantages and Market Positioning
Unique Flush-Reduced Differentiator
Compared with free niacin, it greatly lowers skin flushing incidence while delivering vitamin B3 nutrition, improving consumer adherence to supplement regimens.
Well-Validated European Usage Heritage
Over 30 years of prescription usage in Europe, backed by abundant clinical evidence for safety and functional performance.
Dual-Active Ingredient Benefit
Releases inositol plus niacin upon hydrolysis, consolidating two functional nutrients into one raw material and cutting formula complexity.
Strong Heat & Solid-Form Stability
High melting point and thermal stability make it compatible with tablets, capsules and other conventional solid dosage production.
FAQ (Technical Q&A)
Q1: What is the difference between Inositol Nicotinate and regular niacin?
A: It is an esterified form of niacin that releases niacin gradually without causing skin flushing.
Q2: What is the recommended dosage of this ingredient?
A: Common dosage in dietary supplements is 500-3000 mg/day in divided doses with meals. Specific dosage depends on nutritional claims and regulatory requirements.
Q3: What about the water solubility of this ingredient?
A: Slightly soluble in water, freely soluble in organic solvents such as ethanol, hot DMSO, and DMF. Organic solvents or solid dispersion techniques are recommended in formulations.
Q4: How is this ingredient metabolized in vivo?
A: 1 g hydrolyzes to yield approximately 0.91 g niacin and 0.22 g inositol. Hydrolysis is slow, thus prolonging action duration.
Q5: Are there side effects?
A: Adverse effects are generally mild, primarily headache and mild flushing, but incidence is significantly lower than free niacin.
Q6: What are the cosmetic benefits of Inositol Nicotinate?
A: The inositol component provides moisturizing and skin-conditioning benefits.
Q7: What is the melting point of Inositol Nicotinate?
A: 254-262°C.
Q8: What end products is this ingredient suitable for?
A: Dietary supplements, pharmaceutical excipients, functional foods, and cosmetics.
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