Shandong Changrui Biotech Co., Ltd. is one of the leading manufacturers and suppliers of creatine ethyl ester hydrochloride in China. Please feel free to wholesale bulk high purity creatine ethyl ester hydrochloride in stock here from our factory. All our raw materials are with high quality and competitive price. Contact us for pricelist.
Product Introduction
Creatine Ethyl Ester Hydrochloride is a lipid-soluble prodrug of creatine generated through esterification, in which the ethyl ester group modifies the creatine carboxyl group to significantly enhance molecular lipophilicity and enable more efficient cell membrane penetration. Unlike creatine monohydrate, this product exhibits excellent stability in strongly acidic environments but rapidly hydrolyzes under neutral or alkaline conditions. Its core value lies in the high membrane permeability conferred by the lipid-soluble ester structure, suitable for developing sports nutrition products with higher absorption efficiency requirements, making it a highly differentiated lipid-soluble creatine ester in the creatine ingredient category. Assay ≥99.0%, manufactured at scale in our own factory with batch-specific COA and MSDS included.
Technical Specifications
|
Property |
Specification |
|
Appearance |
White crystalline powder |
|
Assay |
98.0% min |
|
Chloride Content |
19.0-19.5% |
|
Loss on Drying |
1.0% max |
|
Residue on Ignition |
0.1% max |
|
Heavy Metals (as Pb) |
10 PPM max |
|
Arsenic (As) |
1 PPM max |
|
Sulfate (as SO₄) |
0.01% max |
|
Ammonium Salt (as NH₄) |
0.02% max |
|
Clarity of Solution |
Colorless and clear |
|
Total Plate Count |
1000 CFU/g max |
|
Mold & Yeast |
100 CFU/g max |
|
E. coli |
Negative |
|
Salmonella |
Negative |
Health Benefits & Values
Improved Creatine Membrane Absorption
Ethyl ester modification increases lipophilicity for better transmembrane transport, delivering higher creatine uptake into muscle tissue for high-absorption product claims.
Protects Creatine From Gastric Breakdown
The ester structure shields creatine during stomach transit, reducing degradation before intestinal absorption and suiting users sensitive to regular creatine.
Accelerates Muscle Creatine Loading
Faster absorption speeds up intramuscular creatine saturation, perfect for pre-workout supplements focused on rapid nutrient loading.
Boosts Explosive Anaerobic Power
Higher muscle creatine stores rapidly regenerate ATP during short bursts, supporting peak strength and power for strength athletes.
Enables Simple Low-Dose Supplementation
Superior absorption allows effective results at smaller serving sizes and simplifies daily supplementation for end consumers.
Core Value in Formulation Development
Lipophilic Structure for Enhanced Absorptio
The ethyl ester modification increases fat solubility, supporting efficient intestinal absorption and differentiating it from hydrophilic creatine forms.
Optimised For Capsule & Small-Serving Powder Designs
High absorption efficiency allows lower inclusion rates in finished formulas. It reduces fill volume for hard capsules and cuts powder quantity for single-serve stick packs, optimising packaging and formulation costs.
Broad Compatibility With Common Sports Nutrition Ingredients
Stable under typical dry blending conditions, compatible with amino acids, B vitamins, herbal extracts and electrolyte compounds. It integrates smoothly into multi-ingredient pre-workout and strength-support blends.
Dry Form Superiority; Liquid Formulation Constraints
The powder maintains good stability under sealed dry storage. In aqueous environments, ester bonds gradually undergo hydrolysis, splitting back into creatine and ethanol. Liquid finished goods require short shelf-life planning or low-temperature storage to slow ester degradation.
Simplified Labelling Story For High-Absorption Lines
The ester modification provides a clear, easy-to-communicate technical narrative for brand marketing, helping formulators construct high-bioavailability product stories without complex formulation tricks.
End-Application Scenarios
High-Absorption Pre-Workout Powder (Core Track)
Applied in dry-blend pre-workout supplements, leveraging its membrane permeability feature for fast muscle creatine loading.
Hard Shell Capsule Formulations
Perfect for capsule production, its low required filling weight makes it ideal for small-size capsules, solving the large-powder-volume pain point of standard creatine monohydrate capsules.
Single-Serve Stick Sachets & Mini Portable Supplements
Suited for compact portable single-shot sachet products. Lower serving mass reduces stick pack size, convenient for on-the-go athlete supplement lines.
Strength & Power Training Targeted Supplements
Formulated for products focused on explosive power, weightlifting and sprint training, where fast ATP replenishment is the core selling point.
Multi-Ingredient Premium Sports Nutrition Blends
Combined with amino acids, vitamin complexes and performance botanicals for high-end compound sports nutrition products built around bioavailability advantages.
Application Advantages and Market Positioning
Unique Lipophilic Ester Modification
Unlike ionic creatine salts, this product adopts covalent ethyl ester modification to raise lipophilicity. This molecular trait creates its core competitive distinction within advanced creatine derivative portfolio.
Clear High-Bioavailability Selling Proposition
The improved transmembrane uptake gives brands a straightforward differentiator to compete against commodity monohydrate and standard creatine salt products in premium supplement markets.
Target Audience & Brand Profile
Ideal for supplement developers focusing on portable capsule, mini stick-pack and premium high-absorption product series, targeting fitness consumers seeking fast-acting creatine with gentle digestive properties.
Growing Demand For Advanced Absorption Ingredients
Market demand for enhanced-bioavailability sports nutrition raw materials keeps rising, creating steady commercial demand for modified creatine variants beyond basic monohydrate.
FAQ (Technical Q&A)
Q1: What is the core difference between this item and Creatine Monohydrate?
A: It is a lipid-soluble esterified prodrug of creatine with enhanced membrane permeability. Monohydrate is water-soluble creatine. Their absorption mechanisms and formulation systems differ.
Q2: Is it suitable for liquid formulations?
A: Yes, in strongly acidic conditions (pH 1.0-3.0). Prepare fresh or store refrigerated.
Q3: What is the recommended dosage of Creatine Ethyl Ester Hydrochloride?
A: 2-3 g as active creatine per serving in sports nutrition powders and acidic beverages. Specific dosage depends on nutritional claims and regulatory requirements.
Q4: What is the pH stability of Creatine Ethyl Ester Hydrochloride?
A: Half-life reaches 570 hours at pH 1.0; only about 23 seconds above pH 8.0. Formulations should maintain system pH in the acidic range.
Q5: How does this product differ from Creatine HCl?
A: Creatine HCl is a salt of creatine and hydrochloric acid with high water solubility and an acidic solution but intact creatine structure; it is an esterified derivative with lipophilicity, stable in acidic environments, rapidly hydrolyzing in neutral environments. Chemically completely different.
Q6: Does this product degrade in aqueous solution?
A: Yes. It degrades rapidly in neutral to alkaline environments but is stable in strongly acidic conditions (pH 1.0-3.0).
Q7: Can you customize premix blends?
A: Yes. Custom premix blends with other sports nutrition ingredients supported, with formulation development and compatibility testing.
Q8: Can it be used in pet nutrition?
A: Yes. It can be used in canine and feline sports recovery and energy support supplements.
Q9: What is the chloride content?
A: Chloride content is 19.0-19.5%, an important quality indicator for the hydrochloride salt form, with testing data provided in each batch COA.
Q10: What is the core competitive advantage of Creatine Ethyl Ester Hydrochloride compared to other creatine forms?
A: High membrane permeability and strong acid stability.
Q11: What applications is it best suited for?
A: Acidic RTD beverages, high-absorption powders, pre-workout capsules, and premium differentiated products.
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